Microsoft Word - 2-clmn manuscript.docx

نویسندگان

  • R. M. Ferguson
  • A. P. Khandhar
  • K. M. Krishnan
چکیده

Magnetic Particle Imaging (MPI) shows promise for medical imaging, particularly in angiography of patients with chronic kidney disease. As the first biomedical imaging technique that truly depends on nanoscale materials properties, MPI requires highly optimized magnetic nanoparticle tracers to generate quality images. Until now, researchers have relied on tracers optimized for MRI T2*-weighted imaging that are suboptimal for MPI. Here, we describe new tracers tailored to MPI’s unique physics, synthesized using an organic-phase process and functionalized to ensure biocompatibility and adequate in vivo circulation time. Tailored tracers showed up to 3x greater SNR and better spatial resolution than existing commercial tracers in MPI images of phantoms.

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تاریخ انتشار 2014